The 1x1-tES is the ultimate research tool for non-invasive electrical stimulation of the brain. The Soterix Medical 1x1 transcranial Electrical Stimulation (1x1-tES) device is the most sophisticated and precise stimulator ever designed for tDCS, tACS, tPCS, and tRNS. The 1x1 tES represents a decade of biomedical and industrial design to...


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The 1x1-tES is the ultimate research tool for non-invasive electrical stimulation of the brain. The Soterix Medical 1x1 transcranial Electrical Stimulation (1x1-tES) device is the most sophisticated and precise stimulator ever designed for tDCS, tACS, tPCS, and tRNS. The 1x1 tES represents a decade of biomedical and industrial design to create a device that combines unmatched flexibility, reliability, and easy-of-use through unique Soterix Medical features and the Open-Panel™ interface.

The Soterix Medical 1×1 is the clinical standard device when precision and safety cannot be compromised. The Open-Panel™ control panel allows simple set-up and monitoring. Exclusive features including SMARTscan™, RELAX™, and TrueCurrent™ ensure every run is successful. The Soterix Medical 1×1 tES device adopts the same engineering and design principles that established the 1x1 tDCS devices as the industry standard. 1x1-tES is designed to provide the following unique features.

1×1 tES: The Soterix Medical 1×1 tES device adopts the same engineering and design principles that established the 1x1 tDCS (Direct Current Stimulation) devices as the industry gold-standard. For 5 years, the 1x1 platform provides industry leading quality, precision, and usability. Reliable devices are critical exactly because waveform errors can go un-noticed, invalidating all data collected and putting subjects at risk. Researchers and clinicians choose the 1x1 when quality, data integrity, and safety cannot be compromised.

Precision and consistency: Un-paralleled control of alternating signal (AC) fidelity. A clean and precise waveform underpins reproducibility. Validated using realistic loads, the Soterix Medical 1x1 tACS is the trusted standard for unmatched precision. All stimulators are not made equal and the 1x1 tACS guarantees clean sinusoidal output even under non-ideal conditions. The neurophysiological, and so behavioral, effects of tACS are underpinned by the fidelity of the waveform.

Open-Panel™ design: Focus on the trial and on your subjects, not on the device. No drop down menus. No complex hidden features. No need to a separate computer. The Soterix Medical Open-Panel™ design principle means all settings are easy to program and all status items are clear and backlit. Programming the device is as simple as setting peak current and frequency. A simple set-up is not just fast but the best way to prevent costly errors. While 1x1 easy-to-read backlit displays give you confidence from start to finish.

Validated headgear and accessories for tACS: Soterix Medical designed and tested accessories for each stimulation configuration. The same 1x1 accessories that have defined the standard for tolerability in tDCS are adapted for tACS. Single use electrodes designed for non-invasive stimulation means clinical standards for cleanliness, tolerability, and unmatched trial rigor including sham reliability. Soterix Medical’s exclusive 1x1 headgear allow fast and consistent set-up, making it the system of choice in the largest and more rigorous clinical trials. Based on the principle that “In Advanced Neuromodulation One Size Does Not Fit All”, our accessories need to be designed and tested for tACS.

Unique features and special waveforms: Available on select models, unique usability features such as RELAX™, TICKLE™, TRUEcurrent™, and SMARTscan™-AC are re-designed and optimized for tACS. In addition to waveform and intensity control, the 1x1 tACS allows users to select conventional biphasic mode or monophasic mode. SMARTscan-AC is the only impedance monitoring system that reliably tracks electrode performance during AC stimulation. Soterix Medical provides expert advice on setting up and implementing tACS.

About transcranial Alternating Current Stimulation

Basics of tACS: transcranial Alternating Current Stimulation (tACS) is a low-intensity sinusoid (less than 2 mA) current across an electrode placed on the head. This causes a low-intensity electric field to oscillate across a targeted brain region. The frequency of this oscillation is set by the frequency of the AC source, which can be easily adjusted on the Soterix Medical 1×1 tACS. The targeted regions can be controlled by using 1x1 Accessories and Soterix Medical Neurotargeting software.

Neuromodulation: The ability of a low-intensity current to entrain oscillations and neurons makes tACS a potential powerful neuromodulatory tool. Researchers and clinicians hypothesize that tACS provides unique capabilities to alter the brain and behavior. Selecting the frequency and intensity of stimulation, as well as electrode locations, is fundamental in determining the outcome. The Soterix Medical 1x1 tACS allows precise reproduction of all established tACS protocols, as well as the flexibility to explore new dose paradigms.

Tolerability of tACS: Proper protocols, accessories, and equipment are required for reproducible and tolerated transcranial electrical stimulation. Soterix Medical optimizes systems for each technique (“In Advanced Neuromodulation One Size Does Not Fit All”) and tACS requires special consideration. Published human trials with tACS indicate that the technique is well tolerated when professional standards and equipment is used. This includes stimulators that provide precise output, even under load variation, and moreover, are engineered to prevent transient under non-ideal conditions, such as sudden changes in impedance (e.g. do to subject movement). All this technology is automatic with the Soterix Medical 1x1 tACS, allowing you to focus on the subject, not on the device. Adverse events associated with tACS include redness (erythema) under and around electrodes, tingling of the scalp during stimulation, and in some cases phosphene (a phenomenon characterized by the experience of seeing light without light actually entering the eye.) The first two are controlled through use of quality single-use electrodes, such as the Soterix Medical EasyPads. Phosphines are not hazardous and in most cases are of retinal origin during tACS - this means that they can be minimized by using montages that limit current flow across the eyes. Simulation software can be used for this purpose including Soterix Medical Neurotargeting.

Oscillations of the brain: Rhythmic neuronal activity is ubiquitous in the human brain. These rhythms originate from a variety of different network mechanisms, which give rise to a wide-ranging spectrum of oscillation frequencies. In the last few years an increasing number of clinical research studies have explored transcranial alternating current stimulation (tACS) with weak current as a tool for affecting brain function. The premise of these interventions is that tACS will interact with ongoing brain oscillations.

tACS is unique: tACS is unlike tDCS because the waveform oscillates. tACS is unlike Cranial Electrotherapy Stimulation; as tACS provides a well-defined and known signal to entrain brain activity. Cranial Electrotherapy Stimulation devices provide diverse and often poorly defined pulse trains with limited control on montage and brain targeting. tACS is unlike invasive techniques that use high-intensity pulses, because it provides a smooth modulation not possible with pulses. Soterix Medical 1x1-tACS is designed based on scientific principles of AC modulation and is the only device specially designed for tACS.

Oscillations and behavior: Researchers understand that oscillations are ubiquitous in the human brain, ranging from ultra-slow (0.05 Hz) to ultra-fast oscillations (500 Hz). These oscillations occur in the brain during different behavioral states and their power (amplitude) is commonly modulated during cognitive/behavioral tasks. Moreover, abnormal brain rhythms have also been shown to correlate with pathological conditions, like Parkinson’s disease, Alzheimer’s, and epileptic seizures. Researchers designed tACS on the assumption that modulating brain rhythms has the potential to affect cognitive performance and may be used to treat neurological disorders. Therefore, picking the right stimulation output, and choosing a device that generates signal with high fidelity, underpins tACS. Soterix Medical biomedical engineers are ready to work with you on trial design. Our unique HDexplore software provides a module design used to optimize tACS electrode placement in order to target brain regions.

Research grade equipment: At the single cell level, weak AC current applied to the brain will sinusoidally alter the transmembrane potential. with each cycle of the sinusoid, the membrane polarizes up and down. The frequency of tACS sets how quickly the membrane oscillates, while the peak intensity of tACS sets the peak membrane polarization. But in the brain, neurons are not isolated. Neurons are tightly coupled by synapses and, in fact, work together to generate oscillations. In such a situation, weak AC current can modulate the oscillations, potentially increasing their power. Many questions remain about the mechanisms of tACS and Soterix Medical is proud to provide the most state-of-the-art stimulator to support this research.

The Complete System for tES

Complete Waveforms

The Soterix Medical 1x1 tES device provides reproduction of tDCS, tACS, tPCS, and tRNS protocols used in clinical trials. The 1x1 tES is thus a single device that be programmed to provide a broad range waveforms. For any tES waveform, a matched sham waveform is enabled simply by engaging the sham switch. The Soterix Medical 1x1 tES is thus the best option for research labs that want the flexibility to test across tES waveforms with the established reliability and precision of the Soterix Medical 1x1 platform.

Soterix tES Device Waveforms

Soterix Medical Quality

The Soterix Medical brand represents the highest quality and standards in tES because each device is designed based on the latest science and biomedical engineering. The Open-Panel™ interface provides the simplest most-intuitive interface while embedded electronics work over-time to ensure precision and tolerability, even under unexpected conditions. Advancing the practice of tDCS requires devices and protocols integrating the latest advances in technology and science. Soterix Medical was founded to support this effort and continues to provide unparalleled support to every user - with devices and accessories that incorporate exclusive features for rigorous trial design, tolerated procedures, and reproducible protocols. Introduced in 2014, the 1x1-tES stimulator represents the most sophisticated stimulator ever built for tES while building on the validated 1x1 platform.

The most essential feature of a programmable tES device is precision and control of current output. The Soterix Medical 1x1 tES uses state-of-the-art electrical and biomedical engineering design to provide the highest temporal and intensity precision of any tES stimulation device: Adjustable output current in increments of 10 µA, 12 bit D/A, variable sampling time for accurate reconstruction of higher frequencies - 71 µs resolution for 200Hz signals.

Control means that across physiological loads (e.g. head size and electrode impedance), the target current is maintained. Soterix Medical is the only company that provides an independent current meter, the “True-Current” feature, which demonstrates reliability continuously during use. Researchers and clinicians used the Soterix Medical 1x1 tES when the highest quality stimulation signal is required.