HD-Explore was the first commercial software for precision modeling of brain current flow during transcranial
electrical stimulation. And over 5 years HD-Explore has continued to introduce state-of-the-art features in support
of optimized tDCS, tES, HD-tDCS and HD-tES.
Rationally plan HD-tDCS, tDCS and tACS clinical trials
Soterix Medical HD-Explore allows clinicians and researchers to investigate brain targeting for your own HD
configurations. HD-Explore allows clinicians and researchers to rationally plan HD protocols.
Combine HD-Explore with custom modeling for individualized analysis
And with HD-Targets to automatically calculate optimized targets
Use HD-Explore to explore HD 4x1 stimulation or any HD montage
HD-Explore comes pre-loaded with three neurologically normal male Adult heads and the Standard MNI 152
Contact SMI for loading additional library heads at any time. For loading your trial specific heads,
SMI your subjects’ anatomical MRI for custom modeling loaded right into HD-Explore.
3D view of segmentation masks of all tissues
3D solid surface and transparent surface views of current flow
Cutting plane and opacity functions for enhanced visualization and post-processing
Simple to use HD-Explore Interface Demo Video
HD-Explore 1, 2, 3 - Easy to use and intuitive interface
Step 1: Select a head from the Soterix model library - Adult (male,
female), pediatric, stroke, custom models
tDCS is a highly versatile and adaptable treatment. Soterix tDCS stimulators and accessories can be simply customized
to address a range of clinical needs. An important clinical challenge is the optimization of stimulation protocols,
including addressing disease-specific and/or patient-specific needs.
Every Soterix Medical Neurotargeting software is enabled for individual optimization of current flow. Using Soterix
Medical solutions, simply upload subject-specific MRIs and the corresponding current flow head model will then
appear inside the subject select drop-down menu in your software. It is easy to consider how variations in your
subjects' anatomy may influence current flow. Then combine this with Soterix Medical Neurotargeting to optimize
Step 2: Select the HD or sponge electrode montage. Simply click the
electrode location and enter the amount of current
Another innovation from Soterix Medical Neurotargeting. Users of HD-Explore can now emulate any conventional (pad)
tDCS/tACS montage: any number of pads, any shape and size, and position on the head. HD-Explore allows you to simply
select a set of HD-electrodes that cover the same region as the emulated pad to re-create brain current flow
produced by the pad. Simulate any existing or new tDCS/tACS montage. And combine any number of tDCS/tACS or HD-tDCS
electrodes with any current. The limit is your imagination.
Step 3: Visualize current flow through the head. Use the simple tools to
plot current density across the brain
3D visualization of segmentation masks. 3D visualization of solid surface and the transparent surface of brain
current flow. Ability to use cutting planes to visualize fields inside the brain at the location of the cut. Ability
to use opacity function to visualize the current flow within the whole 3D volume.
Easy to use software without compromising accuracy
HD-Explore is the only stand-alone modeling software that provides predictions of brain current flow with equivalent
accuracy to the most advanced engineering software. The reason is a breakthrough in how models are solved based on
the principles of linearity and super-position. The result is that Soterix Medical HD-Explore is able to provide
performance comparable to a team of engineers working with a super-computer for days, using a laptop in just
minutes. HD-Explore is the only research grade software used in hundreds of research publications.
Accuracy validated in primates and non human primate subjects and equivalent performance to
research grade software
Models are only as valuable as they are validated. The parameters used in HD-Explore are based on extensive
validation in humans subjects and non-human primates. Making HD-Explore the most trusted stand-alone current flow