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M×N HD Transcranial Stimulation
The most advanced noninvasive neuromodulation platform.Scalable from 5 to 82 concurrent stimulation channels. Available with exclusive Neurotargeting software. High-Definition transcranial Electrical Stimulation is a transformative technology for targeting cortical and deep brain structures with weak currents. Unlike any other neuromodulation technique, High-Definition transcranial Electrical Stimulation is non-invasive, targeted, and can leverage the therapeutic potential, convenience, safety, and cost-advantages of tES. Stimulation is scalable and can be integrated with any research grade EEG system. Integrated Soterix Medical Neurotargeting software and neuronavigation allows precise stimulator programming for brain targeting. Soterix Medical is the exclusive manufacturer and provider of High-Definition (HD) technology.
State-of-the-art neuromodulation system
The MxN is the flagship product of the leader in non-invasive neuromodulation and is backed by Soterix Medical performance guarantee and our unmatched technical support. Soterix Medical introduces the most advanced non-invasive neuromodulation platform ever developed: the M×N line of stimulators. The MxN stimulators comprise of multiple, independent, and isolated channels with one common (or reference) channel. The platform is fully scalable based on 9-channel (M×N-9) and 5-channel (M×N-5) modules. This means you can start with a powerful but economical system and add channels as needed, or break your existing system into independent functioning stimulators.The MxN platform comprises of two stimulators: one exclusively for transcranial Direct Current Stimulation (MXN HD-tDCS) and one for transcranial Electrical Stimulation (MXN HD-tES).
Each channel can deliver either positive or negative Direct Current (tDCS) while the common reference channel balances the residual current to ensure current conservation.
Each channel can deliver either positive or negative Alternating Current (tACS), Pulse Current (tPCS), Random Noise (tRNS), Oscillating Direct Current (tODCS) in addition to Direct Current (tDCS) while the common reference channel balances the residual current to ensure current conservation.
From 5 to 91 channels, all MxN systems allow full control of electrode placement and current, producing unprecedented non-invasive targeting. Exclusive control technology allows true independent current control and monitoring, while custom head-gear allows electrode placement by a minimum of 10-10 or arbitrary positions.
The MxN systems feature the breakthrough Soterix Medical High-Definition (HD) electrodes, the only gel-based electrode validated in human trials to provide reliable and tolerated performance during current stimulation. Don’t be fooled by copy-cat hardware that compromises subjects and trial integrity. HD electrodes are exclusive to Soterix Medical systems.
With so much flexibility, a multi-channel system is only as powerful as the software used to program it. Soterix Medical is the pioneer in software driven NeurotargetingTM. Software and MxN systems are seamlessly integrated.
Neurotargeting™ guided current delivery
All M×N systems are HD-Targets and HD-Explore enabled allowing investigators to leverage automatic and manual dose optimization. Combine M×N with Soterix Medical Custom modeling for individually optimized treatment. Leveraging exclusive Soterix Medical HD-electrodes, the M×N system can be configured for effective DC stimulation without sensation in most subjects. Study design benefits from the first full sensation matched sham protocols and adapt stimulation for susceptible populations and individualize treatment for efficacy and safety.
Target any cortical region with unprecedented focality in a non-invasive system. The 4x1 montage is just the beginning with MxN Stimulator and Neurotargeting software. Maximize current to any deep brain regions. HDexplore and HDtargets allow you to design and evaluate stimulation strategies. Precision and flexibility derives from the number of stimulation channels and the ability to position those channels anywhere on the scalp (not just limited to EEG 10-10).
A programmable multi-channel stimulator is only effective when combined with tools to optimize neuromodulation. All HD systems are compatible with Soterix Medical Neurotargeting software that allows you to develop customized interventions. From 5 to 82 independently controlled stimulation channels, Soterix Medical provides scalable solutions that meet your need and provide expansive flexibility.
Flexible and Expandable with 5× and 9× modules
MxN systems are designed in fully independent 5-channel and 9-channel modules that can be operated independently or stacked. Users can therefore develop modular systems that be expanded up to 82 independent channels for maximum flexibility in current guidance. 5-channel systems (which include a fifth reference channel) provide industry standard HD-tES for deployments such as 4x1 and 2x2. The 9-channel system can be further optimized for multiple targets. Stack systems together to provide modular increase in targeting up to eight 9-channel systems (or 16 5-channel systems). Modular design means you can always expand on existing systems or divide stacked systems.
Why a “return” channel? Several essential reasons. First, the total current from all channels must equal zero – the return channel automatically carries the inverse of the sum of all other channels. Second, only by using a reference channel can the Neurotargeting software be used to rationally optimize current flow. Without Neurotargeting software, optimization of current at each electrode is complex. Finally, the reference channel facilitates stacking – during stacking the reference channel is shared across systems ensuring safety.
Stand-alone M×N-5 and M×N-9 modules are powerful base systems for HD-tES allowing independent control of 5 and 9 channels respectively. Add additional channel modules as needed to these popular base systems. Basic stack of two MxN-9’s allowing for control on 17 independent channels. One channel is shared to ensure safety and performance*. The stack can also be separated and the systems used independently.
OpenPanel™ Controls for Simple and Safe Operation
Soterix Medical design means advanced features and flexibility, not complex controls or programming. The MxN line has interfaces built on the Soterix Medical OpenPanel design philosophy. All control and displays are visible on the back-lit front panel including real-time TrueCurrent monitoring for each channel. No hidden drop down menus which can lead to programming errors. No need to connect to a remote computer which is subject to sudden losses in wireless connectivity. The MxN system is designed from the ground-up to meet Soterix Medical exacting standards for medical device technology. The difference between copy-cat systems is obvious.
Exclusive and Validated Soterix Medical Technology
The Soterix Medical M×N platform presents the only multi-channel systems validated in clinical trials, the only systems qualified with exclusive Soterix HD electrodes, and the only systems guided by Soterix Medical Neurotargeting software. Do not compromise subject safety: Avoid hazardous copycats. Multi-channel stimulation requires scientific rigor.
Each Soterix Medical MxN device feature was developed by our team of biomedical engineers consulting closely with leading clinical centers. Designed to simply set-up, provide continuous warning of a fault condition, and allow for true (independent) current monitoring. These features facilitate reliable and tolerated multi-channel stimulation.
Channel Quality: Provides a continuous visual indication of electrode quality before and during stimulation. From pre-stimulation set-up, to during stimulation monitoring, to post-stimulation confirmation, the Soterix Medical CHANNEL QUALITY feature provides an intuitive and clear indication of electrode contact quality. Use the CHANNEL QUALITY during set-up to adjust electrodes and head-gear for optimal fit. During stimulation, CHANNEL QUALITY provides a constant indication of electrode quality and can be monitored during adjustments (e.g. addition of gel to improve HD electrode contact). After stimulation, CHANNEL QUALITY confirms a successful trial.
True Current: Clearly indicates the actual current supplied at the moment. What other devices promise, the Soterix Medical MxN devices deliver. The individual displays can be monitored throughout (during stimulation ramp-up to confirm target current intensity is achieved, desired current delivery during stimulation, and stimulation ramp-down to confirm end of stimulation).
Auto Sham: Simple and intelligent sham waveforms. An automatic stimulation sham feature that is engaged with a simple switch. Auto-sham automatically calculates and produces a sham waveform based on the indicated “real” waveform. For example, for a corresponding real waveform of 1.5 mA and 10 minutes, auto-sham will provide a ramp up/down to 1.5 mA at the start of stimulation, and again after 10 minutes, with the timer automatically adjusted such that the total run time is exactly matched to the real case. Based on the Soterix Medical OpenPanel™ design principle: with no complicated programming or hidden drop-down menus required.
HD Monitor: Provides continues monitoring of conditions during HD multi-channel stimulation An exclusive technology from the trusted leader in neuromodulation, Soterix Medical HD-monitor is an intelligent oversight system that provides continuous monitoring of current flow conditions and will warn operator should unusual performance be detected. Multi-channel HD stimulation is the most advanced non-invasive neuromodulation system, providing tremendous flexibility to operators. HD-monitor provides a further level of automatic over-sight before, during, and after stimulation.
Scalable: The only platform designed to allow channel upgrades. No other multi-channel stimulation system is engineered to allow for scalability. The exclusive SCALABLE features integrated into every MxN device allows operators to feel comfortable knowing they can begin multi-channel with the most economical option without losing future scalability.
HD Software: HD devices designed to integrate with Soterix Medical Neurotargeting Software. Multi-channel stimulation devices are only as customizable as the software used to design montages. With independent current control at each electrode with MxN devices, device power and flexibility requires intelligent montage design software. Neurotargeting software is the exclusive Soterix Medical solution to montage design and our MxN stimulators integrate seamlessly. Clinicians and scientists trust Soterix Medical engineers to provide the modeling and software sophistication to fully leverage HD-tDCS and HD-tES